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Karmi-Melamede was born on December 24, 1936, in Tel Aviv, in Mandate Palestine (now Israel). She studied at the Architectural Association School of Architecture in London from 1956 to 1959 and at the Technion – Israel Institute of Technology from 1961 to 1962, being awarded her degree in 1963. She has taught at Columbia University (1969-1982), Yale University (1985, 1993), and the University of Pennsylvania (1991).